PhaSePred: A Meta-predictor For Phase-Separating Proteins
Liquid-liquid phase separation (LLPS) mediates the
compartmentalization of proteins and nucleic acids in cell. This process is driven by multivalent weak interactions
mediated by intrinsically disordered regions (IDRs) or multiple modular domains. A
difference between these two interactions is that a single species
can undergo IDR-mediated phase separation, while phase separation mediated by multiple interacting
domains often involves two or more different protein species. Herein, we characterize proteins that
can self-assemble to form condensates as self-assembling phase-separating proteins
we define proteins whose phase separation behaviors are regulated by partner components as
partner-dependent phase-separating proteins (LLPS-Part).
PhaSePred is a centralized resource that provides self-assembling and partner-dependent phase-separating protein prediction and integrates scores from several LLPS-related predicting tools.